Ethyl-isopropyl-barbituric acid.



lt h Tllh TJAMBERT THORP, 0F DETEJGI'Z',

- ETL-ISOPROPYIPBAEBETUBJC firtiltll Ho "mine".

To all whom it may concern:

lie it known that l, IJABIBERT 'lnonr, a citizen of the United States of America, residing at Detroit, in the county of VVayn'e State of Michigan, have invented certain new usetul Improvements in Ethyl-IsopropybBarbituric Acid, of which the following is a specification.

My invention relates to the production of e hitherto unknown hypnotic substance, and has for its object the obtaining of a body Which, While possessing marked hypnotic and sedative powers, is relatively devoid of toxic action. i

it have found that ethylisopropylbarbituric acid or ethylisopropylmalonylurea possesses marked hypnotic i relatively devoid of toxic action. These properties render this substance valuable for medicinal purposes. The average dose is from 0.3 to 0.5 gram. The usual size of the therapeutic dose is 0.25 gram or approxiniutely tour grains. I

The new substance may be represented by the formula:

he specific emmple,two parts by vtiglgt j oil the ethyiisopropyllnalonyl chlorid tainable by the action of phosphorus pentachlerid upon. ethylisopropyhnalonic acid) re mixed with one mixture teen heated in e suitehle- Specification of Letters Potent.

Application filed January 530, 1917.

and sedative powers and a metal, such, for instance malonylurea, the formula or the atom of co 2HOI.

the formula:

art by Weight of urea,

iE titeioltteidl Feb. 32, llh ll io bath to a temperature of l00120 C. tot several hours. The end-point of the reaction is recognized from the fact-that fumes of hydrogen chloi'id cease to be evolved from the mixture. After cooling, the mass of the reaction the solution decolorincd the aid of bone black and then filtered. The ethylisopropylbarbituric acid separates us the filtrate cools.

The new substzince crystallizes from We.- terin the form ct delicate, snow-White needies, melting et lW -li C. It is only very slightly soluble in cold Water; more readily soluble in ho it; easily soluble in alcohol or ether. mg an acid the substance torrns salts, tn

ily soluble in w t The general formula of these salts may be represented as follows:

in which 5?. stands etorn ot any metal. the new substance possessed of a mildly hitter In the claims, for want of a genetic term, ll shall use the "ethylisopropylmalonylis dissolved in boiling-Water,

of the ullralis being read cree as designating both the acid body and Y the salts thereof.

What I claim as my invention is: 1. The new hypnotic body, ethyllsopropyl- Which may be represented by wherein they be either u hydrogen atom 2. The new hypnotic body, ethylisoprop" l malonylurea, which may be represented oy ou eo uu out being an ueitt,

metal such, for instance, as

trout 11*.

Wit

the form of snow-White needles, melting at a mildly bitter taste, and displaying a by 197-198 (1, being only slightly soluble in notic and sedative action, suhstantisilly be cold water, more readi y soluble in hot Wadescribed.

ter, easily soluble in alcohol or ether; form- In testimony whereof I efix my signature. 10 5 ing salts With the alkali metals which are readily soluble in water; being possessed of LAMBERT THORP. 

